VP Preclinical Development

Job Description

Compugen’s VP Preclinical Development is a management member reporting to the President and CEO. This function will oversee the preclinical drug development functions of the organization – from therapeutic lead selection to the completion of preclinical development to IND, including preclinical activities required to support clinical studies. The position will closely work with the management members in charge of computational discovery, research and drug discovery, Technology Innovation and clinical development.

  • Responsible for the establishment and optimal function of a preclinical development unit, consisting of internal positions, CROs and advisors
  • Providing strategic leadership for the preclinical development through the establishment of long-term and short-term goals, plans and budget and ensuring strategic alignment with the overall company value creation objectives and goals
  • Overall responsibility for preclinical development programs from therapeutic lead selection through preclinical development to IND filing and clearance, including preclinical activities required to support clinical studies)
  • Responsibility for all scientific, technical, operational and personnel aspects of the unit
  • Overall management of a team consisting of internal members, external advisors and CROs of the different professional areas (pharmacology, non-clinical safety, CMC, Bio-Assays, regulatory affairs)
  • Selection of preclinical advisors/CROs, supervising and monitoring their performance
  • Ensure the highest quality of the company’s preclinical development processes
  • Coordinate closely with the management members in charge of computational discovery, research and drug discovery and clinical development to deliver high quality lead candidates for clinical development
  • Representing the Company in external meetings, as required (e.g. regulatory authorities, partnerships and SABs)
  • Experience in Immuno-oncology

Job Requirements

  • PhD in a relevant field
  • 15 years of industry experience in roles of increasing size and scale of leadership
  • Proven track record in drug development, leading preclinical programs from lead selection through to IND approval, as well as managing preclinical activities required to support clinical studies; experience is preparing documents for regulatory submission and ability to represent the company before regulators
  • Demonstrated knowledge in the development of novel drug candidates (preferably biologics/antibody therapeutics), preferred within oncology/immuno-oncology
  • Preferred: experience in CMC of biologics
  • Proven experience in contributing to the overall strategic direction of the company’s R&D organization
  • As member of management, proven leadership and interpersonal skills, including ability to work with all levels and areas within the company and gain credibility within management and across functional groups
  • Demonstrated ability to interact effectively with SAB members, the board of directors and other external advisors
  • Strong experience in building and leading a successful R&D team, including the selection and management of third-party vendors and collaborators

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