Leadership in target discovery

Overview

Our Main Areas of Focus

  • Immuno-Oncology
  • Autoimmune Diseases

Immuno-Oncology

Compugen predictive discovery capabilities for cancer immunotherapy are focused on novel B7/CD28 like immune checkpoints and other immunomodulatory protein candidates.

Immune checkpoints are negative regulators of the immune system, that play critical roles in maintaining self-tolerance, preventing autoimmunity and protecting tissues from immune collateral damage. These immune checkpoints are often "hijacked" by tumors to restrain the ability of the immune system to mount an effective anti-tumor response. Blocking immune checkpoints is thus a promising approach for activating anti-tumor immunity

Immunomodulatory proteins are proteins capable of modifying or regulating one or more immune functions. Immune checkpoints, including inhibitory receptors and ligands, are one type of immune modulators.

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Immuno-Oncology

Autoimmune Diseases

The immune system is programmed to avoid attacking the body’s own cells and tissues in a mechanism known as self-tolerance. The negative regulators of the immune system, known as immune checkpoints, play a critical role in the maintenance of self-tolerance. In autoimmune diseases self-tolerance is compromised and the immune system mistakenly attacks the body’s own tissues. Autoimmune diseases are characterized by hyperactive immune responses that target self-antigens, leading to chronic inflammation and targeted destruction of tissues and organs. An autoimmune disease can be limited to a single organ or may affect multiple organs and tissues. Autoimmune diseases affect millions worldwide, who may suffer from symptoms ranging from mild rashes to life-threatening conditions when major body organs are affected. Autoimmune diseases are a leading cause of disability and death.

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Autoimmune Diseases